ea0019oc28 | Bone and Calcium | SFEBES2009
Bowl MR
, Mirczuk S
, Cranston T
, Bahl S
, Allgrove J
, Nesbit MA
, Thakker RV
GCMB, which is the mammalian homologue of the Drosophila gene Glial cells missing, encodes a 506 amino acid parathyroid-specific transcription factor that contains: a GCM DNA-binding domain at residues 19176; a predicted nuclear localization signal (NLS) at residues 176193; an inhibitory domain at residues 258347; and two transactivation domains at residues 174263, and residues 428506. To date only six different GCMB mu...